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December 1, 199996 citations

Algorithms for Inferring Qualitative Models of Biological Networks

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TATatsuya AkutsuKyoto University
Satoru Miyano
Satoru MiyanoHuman Genome Sciences (United States)
SKSatoru KuharaKyushu University

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Abstract

Modeling genetic networks and metabolic networks is an important topic in bioinformatics. We propose a qualitative network model which is a combination of the Boolean network and qualitative reasoning, where qualitative reasoning is a kind of reasoning method well-studied in Artificial Intelligence. We also present algorithms for inferring qualitative networks from time series data and an algorithm for inferring S-systems (synergistic and saturable systems) from time series data, where S-systems are based on a particular kind of nonlinear differential equation and have been applied to the analysis of various biological systems.

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Cite This Study

Akutsu et al. (1999) studied this question.

synapsesocial.com/papers/6a165344b11859caecb8e2a2https://doi.org/10.1142/9789814447331_0028
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