Why the study?
Time in therapeutic range (TTR) strongly predicts bleeding and thromboembolic events, motivating this evaluation of mean TTR and predictors of inadequate anticoagulation control.
Population
196 patients taking warfarin for all indications with target INR 2.0-3.0 at one private hospital in Thailand
Design
Retrospective cohort study
Key result
Among patients on warfarin, average TTR was 60.46%, and non-adherence (OR 18.23) and heart failure (OR 7.26) strongly predicted poor anticoagulant control (TTR < 65%).
Authors
Loading...
Non-adherence and heart failure were associated with poor TTR on warfarin; hypothesis-generating for targeted interventions before practice change.
Cohort (n=196)
No
Absolute Event Rate: 43.64% vs 79.09%
p-value: p=< 0.001
Comorbid heart failure, non-adherence, and drug/food interactions are strong predictors of poor anticoagulation control in patients receiving warfarin therapy.
Feungfu et al. (2021) conducted a cohort in Patients receiving warfarin therapy (n=196). Warfarin was evaluated on Mean time in therapeutic range (TTR) in poor control (TTR < 65%) vs good control (TTR ≥ 65%) groups (p=< 0.001). Among patients on warfarin, average TTR was 60.46%, and non-adherence (OR 18.23) and heart failure (OR 7.26) strongly predicted poor anticoagulant control (TTR < 65%).