Cardiorespiratory fitness exhibited a nonlinear, quadratic association with cerebrovascular reactivity to hypercapnia in older adults, increasing up to a VO2peak of ~28 mL/kg/min before declining.
Is cardiorespiratory fitness associated with cerebrovascular reactivity to a breath-hold stimulus in middle-aged and older adults?
Cardiorespiratory fitness has a nonlinear association with cerebrovascular reactivity in older adults, suggesting that prior conflicting findings were likely due to studying narrow fitness ranges.
p-value: p=0.23
Earlier studies evaluating associations between cardiorespiratory fitness (CRF) and cerebrovascular reactivity (CVR) have demonstrated conflicting findings dependent on imaging modality or subject characteristics in individuals across a narrow range of CRF. This study demonstrates that CRF is nonlinearly associated with CVR measured by blood oxygen level dependent (BOLD) fMRI in a large sample of middle-aged and older adults across a wide range of CRF, suggesting that conflicting prior findings are related to the range of CRFs studied.
DuBose et al. (Thu,) conducted a other in Healthy older adults (n=114). Moderate-intensity aerobic exercise training (cycling) vs. Light-intensity exercise (passive cycling) was evaluated on Change in BOLD-CVR over time between intervention groups (p=0.23). Cardiorespiratory fitness exhibited a nonlinear, quadratic association with cerebrovascular reactivity to hypercapnia in older adults, increasing up to a VO2peak of ~28 mL/kg/min before declining.
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