Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis

Figures

• 

  Figure 1. (a) Location of MIEN1 gene on chromosome 17 (q12 position) (b) Surface structure of the MIEN1 protein (PDB: 2LJK), (c) Ribbon representation of MIEN1 protein having α (α1 and α2) helices and β (β1, β2, β3, and β4) sheets; and N- and C-terminus (d) MIEN1 methylated promoter sequence. CpG islands are represented in red lines.

• 

  Figure 2. Microarray data representing the expression pattern of MIEN1 in various tissues. The measurements were obtained for 76 normal human tissues and compartments hybridized against HG-U133A. The Affymetrix MAS5 algorithm was used for array processing and probe sets were averaged per gene [https://www.genecards.org/cgi-bin/carddisp.pl?gene=MIEN1].

• 

  Figure 3. Post-translational modification of MIEN1 protein by protein geranylgeranyltransferase-I (GGTase-I).

• 

  Figure 4. MIEN1 enhances migration and invasion via different routes.

• 

  Figure 5. MIEN1 enhances Akt phosphorylation and NFκB signaling.

• 

  Figure 6. Based on the STRING database, the network of MIEN1 and other protein interactions. Ten differentially expressed proteins formed a network map with the MIEN1 protein.