Key result
Intravenous sulprostone infusion for atonic post-partum haemorrhage was associated with coronary spasm, bradycardia, and asystole requiring 25 minutes of cardiopulmonary resuscitation.
Case Report (n=1)
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Intravenous sulprostone administration for post-partum hemorrhage can cause severe cardiovascular complications including coronary spasm and cardiac arrest, particularly in patients with cardiovascular risk factors.
Sulprostone, a synthetic prostaglandin analogue with potent uterotonic action, has been shown to have a low complication rate in a large series. We present a case of cardiac arrest in a parturient after Caesarean section during continuous infusion of intravenous sulprostone administered for atonic post-partum haemorrhage. She had cardiopulmonary resuscitation for 25 min before spontaneous circulation returned. The sequence of events, the results of investigations carried out during the intensive care unit stay, and the presence of multiple cardiovascular risk factors, suggest that sulprostone caused coronary spasm, bradycardia, and subsequent asystole, similar to other cases described in the literature.
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Lampati et al. (2012) conducted a case report in Atonic post-partum haemorrhage (n=1). Sulprostone was evaluated on Cardiac arrest. Intravenous sulprostone infusion for atonic post-partum haemorrhage was associated with coronary spasm, bradycardia, and asystole requiring 25 minutes of cardiopulmonary resuscitation.
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