Summary The ribonucleic acid (RNA) of mature plasma cells was labeled by giving tritiated cytidine to rats during the proliferative phase of a secondary immune response. Autoradiography of smears of the popliteal nodes taken at intervals up to 30 days after the last dose of tritiated cytidine showed the presence of stable RNA in plasma cell cytoplasm and nuclei. Restimulation with specific and nonspecific antigens had no effect on the number of labeled plasma cells or on their stable, persistent RNA.
No takes yet. Share an insight, caveat, or question.
John J. Miller (1964) studied this question.