Depression in mastocytosis: A neglected dimension of a clonal mast cell disease

Petr Heneberg

doi:10.1016/j.autrev.2026.104100

May 1, 2026Autoimmunity ReviewsOpen Access

Depression in mastocytosis: A neglected dimension of a clonal mast cell disease

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Key Points

This research aims to explore the prevalence of depression in mastocytosis patients and the potential role of mast cells and histamine in mental health.
Analyzed patient data to assess rates of depression in those with mastocytosis.
Investigated the effects of H3 receptor antagonists on depressive symptoms.
Reviewed psychiatric care practices in the treatment of mastocytosis.
Depression was reported in a significant proportion of mastocytosis patients.
H3 receptor antagonists demonstrated potential antidepressant effects.
Psychiatric care is infrequently integrated into mastocytosis management.

Implication

Finds depression common in mastocytosis, suggesting the need for psychiatric care.

Abstract

• Depression is common in patients with mastocytosis. • Mast cells act at neuroimmune interfaces and meninges. • H3 receptor antagonists show antidepressant-like effects. • Psychiatric care is rarely included in mastocytosis therapy. • Histamine modulation may relieve depressive symptoms.

Discussion

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Cite This Study

Petr Heneberg (2026) studied this question.

synapsesocial.com/papers/6a1689510c924ddd1bd580c7 https://doi.org/10.1016/j.autrev.2026.104100

View Full Paper

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Depression in mastocytosis: A neglected dimension of a clonal mast cell disease

Key Points

Implication

Abstract

Discussion

Cite This Study

Depression in mastocytosis: A neglected dimension of a clonal mast cell disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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