Shows genomic profiling predicts keratoplasty risk in Fuchs endothelial corneal dystrophy, highlighting a new predictive tool.
Abstract In FECD, progression to keratoplasty is unpredictable. We show that genomic risk profiling, including CTG18.1 expansion status and a disease-specific polygenic risk score, predicts keratoplasty risk with findings validated across independent cohorts.
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Liu et al. (2026) studied this question.
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