Kidney transplantation is considered the best therapeutic option for patients affected by end-stage renal failure, but this possibility is limited by a shortage of donors. Living-donor kidney transplantation (LDKD) is a valuable option, frequently limited by immunological incompatibility between donor and recipient. This review will consider the possibility of performing living-donor kidney donation in the case of AB0 blood group incompatibility and the progress that has been made in this field. Kidney-paired donation is one possibility. This technique is the best option if there are numerous available pairs. This approach is possible because of national and international registries. The more diffuse technique is the desensitization of the recipients. Desensitization may be achieved in several ways, which are extensively discussed in this review. Recently, some published studies documented the possibility of enzymatically converting the A or B groups from the cells of the donor to the O group. This approach is only in a nascent stage but may represent the future, eventually associated with mild desensitization.
Salvadori et al. (Mon,) studied this question.