Ligand-Controlled Palladium-Catalyzed Stereodivergent Hydrocyanation of Yne–Sulfonamides: En Route to E - and Z -Trisubstituted α-Enamidonitriles

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This research focuses on controlling the stereochemistry of α-enamidonitriles through ligand effects in palladium-catalyzed reactions.
Utilized palladium catalysts for hydrocyanation reactions.
Experimented with various ligands to determine their influence on stereochemistry.
Analyzed the stereodivergence in creating E- and Z-isomers of trisubstituted α-enamidonitriles.
Successfully produced both E- and Z-isomers of α-enamidonitriles with controlled geometry.
Demonstrated significant variations in yield and selectivity based on ligand choice.
Produced high purity of isomers suitable for further synthetic applications.

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Demonstrates stereodivergent hydrocyanation outcomes in α-enamidonitriles, suggesting synthetic versatility.

isomers, highlighting the critical influence of alkene geometry in synthetic applications.

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Dai et al. (2026) studied this question.

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