Fabrication and Characterization of Bio-Based Aerogels Derived from Bacillus amyloliquefaciens SQ-2 Exopolysaccharides: Structural Characterization and In Vitro Antitumor Activity Analysis

May 25, 2026GelsOpen Access

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The aim is to characterize bio-based aerogels derived from Bacillus amyloliquefaciens SQ-2 exopolysaccharides and analyze their antitumor activity.
Ethanol precipitation and trichloroacetic acid deproteinization to extract crude exopolysaccharide
Sephadex G-100 gel filtration chromatography and DEAE cellulose ion exchange for purification
Characterization using UV scanning, FTIR analysis, SEM, and TGA.
EPS-3791 aerogels exhibited minimal cytotoxicity to normal L929 cells (viability > 90%)
Inhibited growth of A549 lung cancer, MCF-7 breast cancer, and HeLa cervical cancer cells in a dose-dependent manner (IC50 values not specified)
Hindered HeLa cell migration while promoting L929 wound closure, indicating potential therapeutic applications.

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Shows anticancer activity of EPS-3791 aerogels in cancer cells, indicating potential therapeutic benefits.

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Zhao et al. (2026) studied this question.

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