Spiro-[indene-1,2'-indolin] Scaffolds via Rh (III) Catalyzed C-H Activation/[3+2] Spiroannulation

Imtiaj Mondal; Gracy Salam; Sudip Karmakar; Koushik Naskar; Dibas Dandapat; Ng Shereinai Bliss; Moumita Chowdhury; Indubhusan Deb

doi:10.1039/d6cc01624c

January 1, 2026Chemical Communications

Spiro-[indene-1,2'-indolin] Scaffolds via Rh (III) Catalyzed C-H Activation/[3+2] Spiroannulation

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Key Points

This research aims to develop new spiro-[indene-1,2'-indolin] scaffolds using a Rh(III) catalyzed reaction.
Utilized Rh(III) catalysis for C-H activation.
Conducted [3+2] spiroannulation with ynones and 3,3-dimethyl-2-aryl-3H-indole.
Produced scaffolds with an all-carbon C3-quaternary center.
Successfully synthesized C2-spiro-[indene-1,2'-indolin] scaffolds.
Achieved the formation of complex structures with high molecular diversity.

Implication

Demonstrates a new method for creating complex molecular scaffolds using Rh(III) catalysts, suggesting a breakthrough in organic synthesis.

Abstract

An unprecedented [3+2] spiroannulation of 3,3-dimethyl-2-aryl-3H-indole with ynones/ynoates has been exemplified, furnishing architecturally ornamented C2-spiro-[indene-1,2'-indolin] scaffolds bearing an all-carbon C3-quaternary center proceeding via a Rh (III) catalytic cycle. The protocol...

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Cite This Study

Mondal et al. (2026) studied this question.

synapsesocial.com/papers/6a1689eb0c924ddd1bd5898c https://doi.org/10.1039/d6cc01624c

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Spiro-[indene-1,2'-indolin] Scaffolds via Rh (III) Catalyzed C-H Activation/[3+2] Spiroannulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Spiro-[indene-1,2'-indolin] Scaffolds via Rh (III) Catalyzed C-H Activation/[3+2] Spiroannulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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