Photocatalytic method demonstrates radical fluoroalkylation in substrates from aliphatic and aromatic aldehydes, suggesting versatile synthetic applications.
A photocatalytic method for the C–H perfluoroalkylation of N ‐phenylhydrazones is described. The reaction effectively utilizes both fluoroalkyl iodides and bromides as radical precursors, which enables the introduction of a wide variety of fluoroalkyl fragments. Different reaction conditions were required for hydrazones derived from aliphatic and aromatic aldehydes. The obtained α‐perfluoroalkyl‐substituted hydrazones serve as precursors for the synthesis of diverse heterocycles bearing a fluoroalkyl group.
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Svetlakov et al. (2026) studied this question.
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