Rethinking Peptide Developability with Sequence-Only Models: Interpretable Screening of Microplastic-Binding Peptides with Gated Query Pooling

Guangyao Chen; Fengqi You

doi:10.1039/d6sc01486k

January 1, 2026Chemical ScienceOpen Access

Rethinking Peptide Developability with Sequence-Only Models: Interpretable Screening of Microplastic-Binding Peptides with Gated Query Pooling

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Key Points

The research aims to create peptide sequences that effectively bind to microplastics while minimizing associated risks like hemolysis and poor solubility.
Utilized sequence-only models to evaluate peptide sequences
Designed peptides targeting microplastics' hydrophobic nature
Applied gated query pooling for screening and risk assessment
Identified peptide sequences with high binding efficiency to microplastics
Demonstrated reduced hemolysis risk in selected peptides
Achieved improved aqueous solubility compared to conventional designs

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Implication

Examines peptide design to enhance microplastic binding while reducing developability risks.

Abstract

Designing peptides for microplastic targeting is intrinsically multi-objective: sequence motifs that promote adsorption to hydrophobic polymers frequently elevate developability risks, including hemolysis, non-specific adsorption, and poor aqueous solubility. In this...

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Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a168a640c924ddd1bd5909b https://doi.org/10.1039/d6sc01486k

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Rethinking Peptide Developability with Sequence-Only Models: Interpretable Screening of Microplastic-Binding Peptides with Gated Query Pooling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Rethinking Peptide Developability with Sequence-Only Models: Interpretable Screening of Microplastic-Binding Peptides with Gated Query Pooling

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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