Retrospective cohort study evaluates oncologic outcomes linked to calcitonin levels and surgical extent in medullary thyroid carcinoma, suggesting tailored approaches are viable.
Key Points
This study aims to evaluate the effects of individualized treatment versus guideline-recommended surgical approaches in medullary thyroid carcinoma.
Retrospective cohort study of 91 patients with histologically confirmed MTC
Analysis of surgical procedures against clinical guidelines and classification into concordant or deviant levels
Multivariable logistic regression used to identify predictors of persistent disease and metastasis patterns.
23.1% of patients exhibited persistent disease at final follow-up
Higher preoperative calcitonin levels linked to persistent disease (OR 1.02 per 100 pg/mL increase, p=0.042)
Presence of lymph node metastasis increased risk of persistent disease (OR 4.52, p=0.049).