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May 27, 2026Critical Care Science0 citations

Understanding heterogeneity of treatment effect in critical care trials

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BVBharath Kumar Tirupakuzhi VijayaraghavanBBBruno Adler Maccagnan Pinheiro BesenLKLeticia Kawano-Dourado

Key Points

  • This research explores how treatment effects vary among individuals receiving interventions in critical care settings.
  • Analyzed data from randomized controlled trials evaluating various interventions
  • Focused on identifying clinical and biological factors influencing treatment outcomes
  • Found significant heterogeneity in treatment effects across different patient groups
  • Indicated that personalized treatment approaches may enhance patient care and outcomes

Abstract

INTRODUCTION Heterogeneity of treatment effects (HTE) refers to the idea that the effect of an intervention varies between individuals or groups based on clinical, genetic, or other biological characteristics.() True HTE is concerned with non-random variations in the effect of interventions. Randomized controlled trials evaluating any intervention typically provide estimates of the average treatment effect …

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Cite This Study

Vijayaraghavan et al. (2026) studied this question.

synapsesocial.com/papers/6a168ac80c924ddd1bd598efhttps://doi.org/10.62675/2965-2774.20260021
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  5. 5Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care2015 · 284 citations