Review examines virulence regulation in Streptococcus pneumoniae, highlighting therapeutic strategies for disease management.
are provided to highlight context-dependent regulation of disease progression. Finally, this review examines emerging competence regulon-targeted therapeutic strategies, including dominant-negative competence-stimulating peptides and inhibitors of competence induction, which have been shown to suppress transformation and attenuate pneumococcal virulence.
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Chong et al. (2026) studied this question.
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