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This study aims to evaluate serum ferritin levels and their association with weight loss after bariatric surgery.

May 27, 2026Journal of Investigative Surgery0 citationsOpen Access

The Effect of Ferritin on Weight Loss in Patients Undergoing Bariatric Surgery: A Prospective Cohort Study

YWYuxing WangSouth China Agricultural University MZMeng ZhangBeijing Tian Tan Hospital SBShibo BianBeijing Friendship Hospital

Key Points

This study aims to evaluate serum ferritin levels and their association with weight loss after bariatric surgery.
Prospective cohort design with 135 obese patients undergoing bariatric surgery.
Serum ferritin, folate, and vitamin B12 levels were measured preoperatively and at 12 months postoperatively.
Weight loss was assessed using percentage of total weight loss (%TWL) and excess weight loss (%EWL) analyzed by linear regression.
Serum ferritin levels were positively associated with weight loss after bariatric surgery (p<0.001).
Higher ferritin levels correlated with greater percentage of total weight loss and excess weight loss.
Monitoring of serum ferritin and appropriate iron supplementation are recommended for bariatric surgery patients.

Abstract

BACKGROUND: Weight loss may cause nutrient deficiencies that hinder further weight loss. This study aimed to assess serum ferritin, folate, and vitamin B12 levels and examine their roles in weight loss after bariatric surgery (BS). METHODS: In 135 obese patients, serum ferritin, folate, and vitamin B12 levels were measured from baseline to 12 months post-BS. Weight loss was measured by percentage of total weight loss (%TWL) and excess weight loss (%EWL) using linear regression. RESULTS: < 0.001). CONCLUSIONS: Serum ferritin levels were positively associated with weight loss after BS. Monitoring and appropriate iron supplementation are recommended in patients undergoing BS.

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