Objective: To test whether selection bias has affected the reported effect estimate for RNF in comparison to LNF (RD -0.08. 95%CI: -0.23 to 0.07; p = 0.29). Method: Trial adjusted, simulated comparator trial (SCT) based I2 test for single randomised controlled trials, using revised I2 threshold limits. Result: A baseline covariate imbalance, either due to chance or due to selection bias was established, being equivalent to selection bias level = B% 40 (Bias category = 2). This level suggests that 40-49% of (20 – 24 of the total 50) subjects were non-randomly allocated in favour of one treatment group above the other. Conclusion: The effect estimate reported by the tested trial does not suggest any significant differences between RNF and LNF in reducing reflux symptoms. However, the selection bias level, estimated by use of the trial adjusted, SCT based I2 test for single RCTs (B% = 40), appears to be high enough in order to have affected the reported estimate. In line with new findings, this report updates previous report to the same RCT: EBSM Volume 2, Issue 1, 2026 Pages 13-15, DOI: 10.5281/zenodo.17760805.
Steffen Mickenautsch (Mon,) studied this question.
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