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May 27, 2026Prenatal DiagnosisOpen Access

Prenatal and Perinatal Outcomes in Fetuses With Macrocystic Congenital Pulmonary Airway Malformations: Thoracoamniotic Shunting Versus Expectant Management

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Authors

LCLaurence CarmantAKAlexandria KellySLSeungWoo Lee

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Overview

Retrospective cohort study compares perinatal outcomes in fetuses with macrocystic CPAM treated with thoracoamniotic shunting or managed expectantly, highlighting significant differences.

Key Points

  • This study aims to assess the prenatal imaging characteristics and perinatal outcomes of fetuses with macrocystic congenital pulmonary airway malformations treated with thoracoamniotic shunting versus expectant management.
  • Conducted a retrospective cohort study of 123 fetuses with isolated macrocystic CPAM at Ontario Fetal Center from 1998-2024.
  • Reviewed prenatal ultrasound features, perinatal outcomes, and postnatal surgical data for both management approaches.
  • Identified predictors of mortality in the thoracoamniotic shunting group.
  • Thoracoamniotic shunting was performed in 30 out of 123 cases (24%).
  • Shunted fetuses had a CPAM volume ratio of 1.5 compared to 0.5 for expectantly managed (p<0.01).
  • Neonatal respiratory support was required in 86% of shunted cases versus 25% of expectantly managed cases.

Cite This Study

Carmant et al. (2026) studied this question.

synapsesocial.com/papers/6a168b160c924ddd1bd59f99https://doi.org/10.1002/pd.70172
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