From Onset to Outcome: A Long-term Retrospective, Single centre Study of Guttate Psoriasis from Israel

Guttate psoriasis is often precipitated by strepto-coccal infections and is generally regarded as a mild subtype of psoriasis; however, its potential associations with systemic comorbidities are insufficiently explored. In this study, we aimed to evaluate the association of guttate psoriasis with systemic comorbidities such as metabolic syndrome and psoriatic arthritis and identify factors affecting recurrence. In this retrospective single-centercentre study, we reviewed the data of patients with the first eruption of guttate psoriasis between 1998 and 2020 and at least 4 years of follow-up data. Demographic information and medical data (type of treatment, psoriasis flare-ups, remission of disease, and development of metabolic syndrome and/or psoriatic arthritis) were retrieved. Of 395 patients included (mean follow up, 83±34.7 months), 34.9 % experienced at least one recurrence, 14.68 % had multiple recurrences, 5.6 % developed psoriatic arthritis, and 8.6 % had metabolic syndrome. Male sex, topical treatment and residual disease were significant risk factors for recurrence. Psoriatic arthritis was strongly associated with multiple recurrences, while a possible association with metabolic syndrome was observed, highlighting the importance of careful long-term monitoring in this population.