Structural Differences between Two Types of "Heavy Chain" Disease Proteins and Myeloma Globulins of Corresponding Types

Structural differences between two antigenic types (designated C and Z) of gamma-globulins, both of low molecular weight, produced in " Heavy chain" disease are revealed by their relative susceptibilities to enzymatic degradation by papain and the nature of the cleavage products. Corresponding structural differences exist between the respective type C and type Z myeloma gamma(2)-globulins. These structural differences are tentatively assigned to the H-chains, and more specifically to the portion of the H-chain contained in the fast-moving (F) fragment of papain-treated gamma(2)-globulins.