What question did this study set out to answer?

To compare post-transplantation outcomes and survival between reduced-intensity conditioning and myeloablative conditioning in patients with hemophagocytic lymphohistiocytosis.

September 21, 2010BloodOpen Access

Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation

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Authors

RMRebecca MarshCincinnati Children's Hospital Medical Center GVGretchen VaughnCincinnati Children's Hospital Medical Center MKMi‐Ok KimUniversity of California, San Francisco

Discussion

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Implication

Cohort study demonstrates improved survival with reduced-intensity conditioning in hemophagocytic lymphohistiocytosis transplantation, indicating lower treatment toxicity.

Key Points

To compare post-transplantation outcomes and survival between reduced-intensity conditioning and myeloablative conditioning in patients with hemophagocytic lymphohistiocytosis.
Analyzed 40 patients with hemophagocytic lymphohistiocytosis who received allogeneic hematopoietic cell transplantation between 2003 and 2009 at Cincinnati Children's Hospital.
Compared 14 patients treated with myeloablative conditioning (busulfan, cyclophosphamide, and antithymocyte globulin ± etoposide) against 26 patients treated with reduced-intensity conditioning (fludarabine, melphalan, and alemtuzumab).
Estimated 3-year overall survival was significantly higher with reduced-intensity conditioning at 92% (confidence interval = ± 11%) compared to 43% (confidence interval = ± 26%) with myeloablative conditioning (P = .0001).
Acute graft-versus-host disease grades II to III developed in 8% of reduced-intensity conditioning patients versus 14% of myeloablative conditioning patients (P = .3171).
Post-transplantation mixed chimerism occurred in 65% of reduced-intensity conditioning patients compared to 18% of myeloablative conditioning patients (P = .0110), with most cases successfully managed without relapse.

Cite This Study

Marsh et al. (2010) studied this question.

synapsesocial.com/papers/6a1695487d286b2899b256dd https://doi.org/10.1182/blood-2010-04-282392

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September 21, 2010BloodOpen Access

Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation

View Full Paper

Ask AI

Bookmark

Authors

RMRebecca MarshCincinnati Children's Hospital Medical Center GVGretchen VaughnCincinnati Children's Hospital Medical Center MKMi‐Ok KimUniversity of California, San Francisco

Discussion

Member takes

Implication

Cohort study demonstrates improved survival with reduced-intensity conditioning in hemophagocytic lymphohistiocytosis transplantation, indicating lower treatment toxicity.

Key Points

To compare post-transplantation outcomes and survival between reduced-intensity conditioning and myeloablative conditioning in patients with hemophagocytic lymphohistiocytosis.
Analyzed 40 patients with hemophagocytic lymphohistiocytosis who received allogeneic hematopoietic cell transplantation between 2003 and 2009 at Cincinnati Children's Hospital.
Compared 14 patients treated with myeloablative conditioning (busulfan, cyclophosphamide, and antithymocyte globulin ± etoposide) against 26 patients treated with reduced-intensity conditioning (fludarabine, melphalan, and alemtuzumab).
Estimated 3-year overall survival was significantly higher with reduced-intensity conditioning at 92% (confidence interval = ± 11%) compared to 43% (confidence interval = ± 26%) with myeloablative conditioning (P = .0001).
Acute graft-versus-host disease grades II to III developed in 8% of reduced-intensity conditioning patients versus 14% of myeloablative conditioning patients (P = .3171).
Post-transplantation mixed chimerism occurred in 65% of reduced-intensity conditioning patients compared to 18% of myeloablative conditioning patients (P = .0110), with most cases successfully managed without relapse.

Cite This Study

Marsh et al. (2010) studied this question.

synapsesocial.com/papers/6a1695487d286b2899b256dd https://doi.org/10.1182/blood-2010-04-282392

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