Key result
Dietary sodium-driven epigenetic immune cell reprogramming promotes salt-sensitive hypertension development.
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This review highlights the emerging role of epigenetic reprogramming in innate and adaptive immune cells as a contributing mechanism to salt-sensitive hypertension.
Access to excess dietary sodium has heightened the risk of cardiovascular diseases, particularly affecting individuals with salt sensitivity of blood pressure. Our research indicates that innate antigen-presenting immune cells contribute to rapid blood pressure increases in response to excess sodium intake. Emerging evidence suggests that epigenetic reprogramming, with subsequent transcriptional and metabolic changes, of innate immune cells allows these cells to have a sustained response to repetitive stimuli. Epigenetic mechanisms also steer T-cell differentiation in response to innate immune signaling. Immune cells respond to environmental and nutritional cues, such as salt, promoting epigenetic regulation changes. This article aims to identify and discuss the role of epigenetic mechanisms in the immune system contributing to salt-sensitive hypertension.
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Mutchler et al. (2025) conducted a review in Salt-sensitive hypertension. Excess dietary sodium was evaluated. Epigenetic reprogramming of innate and adaptive immune cells in response to excess dietary sodium contributes to the development of salt-sensitive hypertension.
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