PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 1, 1989Statistics in Medicine135 citations

Heterogeneity in the probability of HIV transmission per sexual contact: The case of male‐to‐female transmission in penile—vaginal intercourse

View Full Paper
JWJames WileySHStephen J. HerschkornNPNancy Padian

Key Points

  • The aim is to investigate the variations in HIV transmission probabilities during penile-vaginal intercourse.
  • Modelled infectivity beta as a random variable to represent heterogeneity.
  • Utilized maximum-likelihood estimation with beta and discrete distributions.
  • Analyzed data on contact frequency and seroconversion events between couples.
  • Estimates show extreme heterogeneity in HIV transmission probabilities.
  • Model limitations indicate the need for careful interpretation of findings.
  • The results suggest important implications for understanding epidemiological spread.

Abstract

Recent studies have indicated variation in the infectivity beta of HIV among heterosexual couples. We represent this heterogeneity by modelling beta as a random variable. Using data on the number of contacts and seroconversion of couples, we fit the model by maximum-likelihood estimation with a beta distribution and a discrete distribution for beta. The estimates indicate the heterogeneity is extreme. The limitations of the model and the implications of the results for epidemiologic spread and further research are discussed.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Wiley et al. (1989) studied this question.

synapsesocial.com/papers/6a169f56798df06fa4b2585chttps://doi.org/10.1002/sim.4780080110
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Heterosexual Partners, Children, and Household Contacts of Adults With AIDS1987 · 370 citations
  2. 2Differences among human immunodeficiency virus strains in their capacities to induce cytolysis or persistent infection of a lymphoblastoid cell line immortalized by Epstein-Barr virus1987 · 76 citations
  3. 3Transmission dynamics of HIV infection1987 · 781 citations
  4. 4Male-to-Female Transmission of Human Immunodeficiency Virus1987 · 331 citations
  5. 5ASSOCIATION OF DIFFERENT ALLELIC FORMS OF GROUP SPECIFIC COMPONENT WITH SUSCEPTIBILITY TO AND CLINICAL MANIFESTATION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION1987 · 96 citations