Key result
The CFH Tyr402His C allele (OR 2.71; 95% CI 1.25-5.90) and LOC387715 variant (OR 3.47; 95% CI 1.01-11.9) were significantly associated with an increased risk of AMD in a Russian population.
Why the study?
Are CFH Tyr402His and LOC387715 Ser69Ala polymorphisms associated with age-related macular degeneration in an isolated north-west Russian population?
Population
155 patients with age-related macular degeneration and 151 age-matched controls from an isolated north-west…
Comparison
Genotyping for CFH Tyr402His, LOC387715… vs Age-matched controls without AMD
Design
Case-control
Authors
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Supports AMD genetic risk assessment in northwest Russians; extends Western loci findings but leaves clinical adoption open.
Case-Control (n=306)
Are CFH Tyr402His and LOC387715 Ser69Ala polymorphisms associated with age-related macular degeneration in an isolated north-west Russian population?
Effect estimate: OR 2.71 (95% CI 1.25 to 5.90)
p-value: p=0.0035
The CFH gene variant contributes to AMD risk in a north-west Russian population, though with a weaker effect than observed in Western populations.
Galer et al. (1993) conducted a case-control in Age-related macular degeneration (AMD) (n=306). CFH Tyr402His and LOC387715 Ser69Ala polymorphisms vs. Age-matched controls was evaluated on Association of CFH Tyr402His C allele with AMD (OR 2.71, 95% CI 1.25 to 5.90, p=0.0035). The CFH Tyr402His C allele (OR 2.71; 95% CI 1.25-5.90) and LOC387715 variant (OR 3.47; 95% CI 1.01-11.9) were significantly associated with an increased risk of AMD in a Russian population.
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