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BACKGROUND: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth. AIMS: To evaluate the circulating microRNA-21 in glioblastoma patients. METHODS: MicroRNA-21 copies in glioblastoma plasma (n = 10, before surgery and during/after concomitant chemoradiotherapy), control plasma (n = 10), and tissue samples were analyzed using RT-qPCR. RESULTS: MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection. DISCUSSION: Circulating microRNA-21 might be a useful biomarker in glioblastoma.
Ilhan‐Mutlu et al. (Tue,) studied this question.