Key result
Angiotensin-II inhibition lowers mitochondrial oxidant production and protects mitochondrial structure, offering a potential therapeutic strategy for human renal and cardiovascular diseases.
Angiotensin-II blockade may offer therapeutic benefits in human renal and cardiovascular disease by protecting mitochondrial structure and function.
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Hypothesis-generating for mitochondrial protection by Ang-II inhibition in cardiorenal disease; leaves open need for clinical outcome trials.
Cavanagh et al. (2007) conducted a review in Renal and cardiovascular disease. Angiotensin-II inhibition was evaluated. Angiotensin-II inhibition lowers mitochondrial oxidant production and protects mitochondrial structure, offering a potential therapeutic strategy for human renal and cardiovascular diseases.