Key result
Blood dopamine levels were strongly and negatively correlated with suicide risk (r = -0.804) in patients with major depressive disorder, explaining 64% of the variance in suicide risk.
Why the study?
The authors sought to determine whether a connection exists between serotonin and dopamine and the aggression-suicidal risk axis in patients with major depression disorders.
Cross-Sectional (n=113)
No
Effect estimate: r = -0.804
p-value: p=<0.001
In patients with major depressive disorder, lower blood levels of serotonin and dopamine are significantly associated with higher levels of aggression and suicide risk.
Lower dopamine levels were associated with higher suicide risk in MDD; cross-sectional data leave causal and clinical implications open pending prospective studies.
In the present report we want it to see if there is a connection between serotonin and/or dopamine and the aggression-suicidal risk axis in patients with major depression disorders. 113 patients were selected and we used the following specific scales: Hamilton Depression Rating Scale, the Colombia Suicide Risk Scale, and the Buss & Perry Aggression Questionnaire. Serotonin and dopamine were determined by high pressure liquid chromatography. The results of this study are clear in terms of the relationship between neurotransmitters serotonin and dopamine on one hand and aggression and suicide risk on the other. Our analysis of the data reveals significant Pearson correlations with both aggressive serotonin and dopamine and suicide risk. Moreover, following linear regression, both serotonin levels and dopamine levels resulted in significant predictors of aggression and suicide risk. In addition, the social implications of our results are presented and discussed.
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Prepelita et al. (2019) conducted a cross-sectional in Major Depressive Disorder (n=113). Blood serotonin and dopamine levels was evaluated on Correlation between blood dopamine level and suicide risk (r = -0.804, p=<0.001). Blood dopamine levels were strongly and negatively correlated with suicide risk (r = -0.804) in patients with major depressive disorder, explaining 64% of the variance in suicide risk.
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