Key result
Electrically controlled thermal activation between 10°C and 50°C provided rapid and reversible on-off control of actomyosin biomolecular motors without functional loss.
Electrically controlled thermal activation provides an effective method for turning actomyosin-powered nanoactuators on and off.
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May enable reversible nanoactuator control in experimental systems; leaves open translation to cardiovascular applications.
A fast all-electrical activation and control mechanism for biomolecular motor-powered nanoactuators has been developed. Rapid and reversible on–off control of actomyosin biomolecular motors was experimentally demonstrated using in vitro motility assays. The results show that the motility of the actin filaments can be cycled repeatedly by electrically controlled thermal activation in the temperature range from 10°C to 50°C without functional loss. The fast response of the filaments upon rapid temperature switching suggests that thermal activation provides an effective method for turning actomyosin-powered nanoactuators on and off.
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Mihajlović et al. (2004) studied this question. Electrically controlled thermal activation was evaluated on Motility of actin filaments. Electrically controlled thermal activation between 10°C and 50°C provided rapid and reversible on-off control of actomyosin biomolecular motors without functional loss.
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