Key result
Systematic programmed atrial stimulation induced sustained supraventricular tachycardia in 40.5% of patients with chronic myocardial infarction compared to 11% of patients without heart disease.
Why the study?
Does systematic programmed atrial stimulation predict the development of sustained supraventricular tachycardia in patients with chronic myocardial infarction?
Observational (n=446)
Does systematic programmed atrial stimulation predict the development of sustained supraventricular tachycardia in patients with chronic myocardial infarction?
Inducible supraventricular tachyarrhythmias are common in patients with chronic myocardial infarction and are highly predictive of future spontaneous SVT episodes.
Inducible SVT may predict spontaneous episodes in chronic MI; leaves open prospective validation before guiding practice.
In order to evaluate the incidence and significance of inducible supra-ventricular (SVTA) in patients with chronic myocardial infarction (MI), the results of systematic programmed atrial stimulation were compared in two groups of patients: 150 patients (group I) without MI or underlying heart disease, studied for syncope or conduction disturbances, 296 patients (group II) studied after an acute Mi (greater than 1 month). None of them had spontaneous SVTA, and 24-h Holter monitoring showed no SVTA. The atrial stimulation programme used one and two extra stimuli delivered during sinus rhythm and atrial pacing (600 ms and 10% less than the sinus cycle length). A sustained (S) (greater than 30 s) supraventricular tachycardia (SVT) (atrial flutter, fibrillation, tachycardia) was induced in 17 patients in group I (11%) and in 120 patients in group II (40.5%). In group II inducible SVTA could not be correlated with the occurrence of a SVT during acute MI, the location of MI, the value of LV ejection fraction (EF), the incidence of inducible sustained ventricular tachycardia (VT), or fibrillation (VF). However, inducible SVTA could be correlated with a significantly shorter effective atrial refractory period (197 +/- 23 ms vs 220 +/- 35 ms, P less than 0.001) and a shorter retrograde block cycle length (518 +/- 215 vs 585 +/- 215 ms, P less than 0.03). The patients in group II were followed-up for at least 6 months; 12 of them developed sustained episodes of supraventricular tachycardia; 11 of them had inducible SVTA (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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Brembilla-Perrot et al. (1991) conducted an observational in chronic myocardial infarction (n=446). Systematic programmed atrial stimulation vs. Patients without MI or underlying heart disease was evaluated on Induction of sustained supraventricular tachycardia (>30 s). Systematic programmed atrial stimulation induced sustained supraventricular tachycardia in 40.5% of patients with chronic myocardial infarction compared to 11% of patients without heart disease.
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