Quantitative cardiovascular magnetic resonance using T2 mapping reliably detected acute myocarditis and discriminated between acute and healed stages, with 100% diagnostic accuracy for T2 ratio >1.9.
Case-Control (n=36)
Does quantitative cardiovascular magnetic resonance (T1 and T2 mapping) accurately detect and monitor acute myocarditis compared to healthy controls?
Quantitative CMR using T1 and T2 mapping reliably detects acute myocarditis, but T2 mapping provides incremental value by discriminating between acute and healed stages.
Absolute Event Rate: 55.1% vs 50.2%
p-value: p=<0.001
Background— Cardiovascular magnetic resonance based on the Lake Louise Criteria is used to make the diagnosis of acute myocarditis. Novel quantitative parametric mapping techniques promise to overcome some of its limitations. We aimed to evaluate quantitative cardiovascular magnetic resonance to detect and monitor acute myocarditis. Methods and Results— Eighteen patients with clinical diagnosis of acute myocarditis (25 years 23–38 years; 78% males) were prospectively enrolled and repeatedly underwent cardiovascular magnetic resonance at 1.5 T seven days (5–10 days) after symptom onset (FU0), after 5 weeks (FU1), and after 6 months (FU2). Eighteen age- and sex-matched healthy subjects served as controls. Cardiovascular magnetic resonance included imaging of edema, hyperemia, necrosis, and fibrosis using semiquantitative T2-weighted spin echo, T2 mapping, and T1 mapping before and 3 and 10 minutes after gadobutrol administration. Extracellular volume for diffuse and late gadolinium enhancement for focal fibrosis were assessed. Compared with controls, patients had significantly higher global T2 times at FU0 (55.1 ms 53.3–57.2 ms versus 50.2 ms 49.2–52.0 ms; P 52 ms, 78% for native T1>981 ms, 74% for extracellular volume fraction >0.24, and 100% for T2 ratio >1.9. Conclusions— Although both T2 and T1 mapping reliably detected acute myocarditis, only T2 mapping discriminated between acute and healed stages, underlining the incremental value of T2 mapping.
Knobelsdorff‐Brenkenhoff et al. (Wed,) conducted a case-control in Acute myocarditis (n=36). Quantitative cardiovascular magnetic resonance (T1 and T2 mapping) vs. Healthy controls was evaluated on Global T2 times at 7 days (FU0) in ms (p=<0.001). Quantitative cardiovascular magnetic resonance using T2 mapping reliably detected acute myocarditis and discriminated between acute and healed stages, with 100% diagnostic accuracy for T2 ratio >1.9.