Key result
Tumor necrosis factor alpha-induced endothelial tissue factor is predominantly located on the basolateral cell surface rather than the subendothelial matrix, with matrix TF representing cell remnants.
Population
Cultured human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor alpha
Design
Preclinical
Authors
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Questions matrix TF contribution to thrombosis; leaves open relevance of basolateral endothelial TF in human disease.
Induced endothelial tissue factor is primarily located on the cell surface rather than the subendothelial matrix, with apparent matrix TF resulting from cell remnants left by certain detachment methods.
Mulder et al. (1994) studied this question. Tumor necrosis factor alpha was evaluated on Tissue factor (TF) activity and distribution. Tumor necrosis factor alpha-induced endothelial tissue factor is predominantly located on the basolateral cell surface rather than the subendothelial matrix, with matrix TF representing cell remnants.
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