Key points are not available for this paper at this time.
ABSTRACT Solitary fibrous tumor (SFT) is a fibroblastic neoplasm with NAB2 and STAT6 gene fusion as well as STAT6 nuclear expression. Uncommon variants of intracranial SFTs, such as glandular and papillary structures, are extremely rare. We present a rare SFT case in a 64‐year‐old female demonstrating unprecedented glandular structures and extensive myxoid stromal changes. This morphologic divergence underscores the imperative for molecular validation in SFTs with atypical histologic features. Our findings advocate a refined diagnostic protocol: RNA‐based next‐generation sequencing (RNA‐NGS) must be prioritized in STAT6‐immunopositive central nervous system (CNS) mesenchymal tumors when DNA‐NGS fails to identify the pathognomonic NAB2::STAT6 fusion, as demonstrated by the resolution of diagnostic ambiguity through detection of a cryptic NAB2‐exon4::STAT6‐UTR fusion in this case.
Xu et al. (Mon,) studied this question.