Common carotid artery distensibility was significantly lower in renal transplant recipients who developed cardiovascular events compared to those who did not (12.2 vs 16.8 10-3/kPa, P<0.005).
Cohort (n=68)
Does reduced carotid artery distensibility predict cardiovascular events in asymptomatic renal transplant recipients?
Reduced carotid artery distensibility is an independent predictor of future cardiovascular events in asymptomatic renal transplant recipients.
valor p: p=<0.005
OBJECTIVE: Arterial distensibility is reduced in end-stage renal failure and also after renal transplantation. The aim of the present study was to test the hypothesis that reduced carotid artery distensibility is a predictor of cardiovascular disease in patients after renal transplantation. SUBJECTS AND METHODS: Sixty-eight asymptomatic renal transplant recipients were studied between March 1990 and December 1992, 3-6 months after transplantation. The mean duration of follow-up was 95 +/- 2 months (mean +/- SEM). At entry, vessel wall movements of the common carotid artery were recorded using a pulsed multigate Doppler system; blood pressure was measured by sphygmomanometry. RESULTS: Nineteen cardiovascular events (CVE) occurred during follow-up, leading to death in six cases. The distensibility coefficient of the common carotid artery was significantly lower in patients with CVE than in those without CVE (12.2 +/- 1.0 10-3/kPa versus 16.8 +/- 0.7 10-3/kPa, P < 0.005). Logistic regression analysis showed that the occurrence of cardiovascular disease during follow-up was related to carotid artery distensibility (P < 0.05), independent of sex, age, smoking habits, carotid artery end-diastolic diameter, systolic and diastolic blood pressure levels, heart rate, serum creatinine, cholesterol and haemoglobin levels. Patients with a distensibility coefficient above the age-adjusted mean had a significantly longer interval free of cardiovascular disease than patients with a distensibility coefficient below the age-adjusted mean (P < 0.01). CONCLUSIONS: The distensibility of the common carotid artery is an independent predictor of cardiovascular disease in renal transplant recipients.
Barenbrock et al. (Tue,) conducted a cohort in Renal transplantation (n=68). Carotid artery distensibility was evaluated on Cardiovascular events (p=<0.005). Common carotid artery distensibility was significantly lower in renal transplant recipients who developed cardiovascular events compared to those who did not (12.2 vs 16.8 10-3/kPa, P<0.005).