Key result
Engineered biomaterial environments mimicking early calcific aortic valve disease showed that hyaluronic acid increased VEGF production and chondroitin sulfate retained lipoproteins like oxLDL.
Population
Valvular interstitial cells (VICs) cultured in vitro
Design
Preclinical
Authors
Loading...
May guide mechanistic research on aortic valve disease; leaves open translation from this animal model.
Engineered biomaterial environments mimicking early calcific aortic valve disease demonstrate that specific glycosaminoglycans and oxidized LDL interact to drive a positive feedback loop of valve lesion progression.
Porras et al. (2017) studied calcific aortic valve disease (CAVD). biomaterial environments containing pathological amounts of hyaluronic acid (HA) or chondroitin sulfate (CS) was evaluated on indicators of disease progression (VIC activation, inflammatory cytokine production, VEGF production, lipoprotein retention). Engineered biomaterial environments mimicking early calcific aortic valve disease showed that hyaluronic acid increased VEGF production and chondroitin sulfate retained lipoproteins like oxLDL.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: