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A bibliometric analysis was performed on academic research from 1965 to 2025 with a focus on S-100B protein and acute ischemic stroke (AIS). In total 15,792 academic papers about S-100B protein and AIS were reviewed, showing a sharp incline in publications after 1980. Leading the publications of research and citations were the United States, followed by Japan and Germany, which also had the highest clustered connections as well. The most prevalent organization was the Harvard University. This bibliometric analysis aims to analyze the prognostic value of S-100B protein as a potential biomarker in AIS with global data.
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Gurijala et al. (2025) studied this question.
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