Key result
EGF stimulation induces highly tissue-specific phosphoproteomic and transcriptomic signaling across the heart and other murine organs.
Why the study?
Prior studies in disease models have limited insight into Egfr signaling patterns across healthy tissues.
Does short-term Egf stimulation cause tissue-specific signaling changes in healthy mouse tissues?
Does short-term Egf stimulation cause tissue-specific signaling changes in healthy mouse tissues?
The study reveals that Egfr signaling dynamics in response to Egf stimulation are highly tissue-specific in healthy mice.
Tissue-specific Egfr responses in healthy mice should not alter clinical practice; leaves open translation to human disease and targeted therapies.
or in tissue-specific mouse models of disease, which has limited insight into Egfr signaling patterns in healthy tissues. Here, we carried out integrated phosphoproteomic, proteomic, and transcriptomic analyses of signaling changes across various mouse tissues in response to short-term stimulation with the Egfr ligand Egf. We show how both baseline and Egf-stimulated signaling dynamics differ between tissues. Moreover, we propose how baseline phosphorylation and total protein levels may be associated with clinically relevant tissue-specific Egfr-associated phenotypes. Altogether, our analyses illustrate tissue-specific effects of Egf stimulation and highlight potential links between underlying tissue biology and Egfr signaling output.
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Awasthi et al. (2025) studied Healthy mouse tissues (heart, lung, kidney, liver). Epidermal growth factor (Egf) vs. Vehicle control was evaluated on Tissue-specific phosphoproteomic and transcriptomic changes. Egf stimulation induces highly tissue-specific phosphoproteomic and transcriptomic signaling responses across the heart, lung, kidney, and liver in mice.
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