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The route of in vivo formation of 4-formylaminoantipyrine which is a new metabolite of aminopyrine was examined. As a result of examination by gas chromatography-mass spectrometry and 13C-NMR after oral administration of 13C-labeled aminopyrine to man and experimental animals, formylamino group was formed by oxidation of N-methyl side chain of aminopyrine.
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NODA et al. (1976) studied this question.
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