July 1, 1996Annals of Neurology
Apolipoprotein E and cognitive change in an elderly population
Key result
The apoE epsilon 4 allele modestly increased the risk of developing cognitive impairment (OR 1.37; 95% CI 1.007-1.850; p=0.045), whereas the epsilon 2 allele was protective (OR 0.53).
Why the study?
Does the presence of apoE epsilon 4 or epsilon 2 alleles predict cognitive impairment in an elderly population?
Population
1,899 individuals 65 years and older from the Iowa 65+ Rural Health Study
Design
Cohort
Follow-up
4 to 7 years
Authors
Discussion
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Implication
ApoE genotyping should not guide cognitive risk assessment in the elderly; extends established AD associations to broader cohorts but remains hypothesis-generating.
Study Design
Type
Cohort (n=1,899)
Structured PICO
Does the presence of apoE epsilon 4 or epsilon 2 alleles predict cognitive impairment in an elderly population?
P
Population
1,899 individuals 65 years and older from the Iowa 65+ Rural Health Study
I
Intervention
Presence of apolipoprotein E (apoE) epsilon 4 or epsilon 2 alleles
O
Outcome
Performance on a delayed recall task and development of cognitive impairment over a 4- to 7-year period
Main Result
Effect estimate: OR 1.37 (95% CI 1.007, 1.850)
p-value: p=0.045
ApoE epsilon 4 and epsilon 2 alleles have modest effects on predicting cognitive impairment in the elderly, suggesting limited utility of apoE genotyping as a prognostic indicator.
Cite This Study
Hyman et al. (1996) conducted a cohort in Cognitive impairment (n=1,899). Apolipoprotein E (apoE) epsilon 4 and epsilon 2 alleles vs. Other apoE genotypes was evaluated on Developing cognitive impairment on a delayed recall task (OR 1.37, 95% CI 1.007, 1.850, p=0.045). The apoE epsilon 4 allele modestly increased the risk of developing cognitive impairment (OR 1.37; 95% CI 1.007-1.850; p=0.045), whereas the epsilon 2 allele was protective (OR 0.53).