Key result
A 24-hour fast reduces tolerance to progressive central hypovolemia by ~10% versus a fed state.
Why the study?
Does acute 24 h fasting reduce tolerance to central hypovolemia in humans?
RCT (n=18)
Single-blind
Randomized crossover
No
Does acute 24 h fasting reduce tolerance to central hypovolemia in humans?
Prolonged fasting may lead to quicker decompensation during central hypovolemia due to blunted peripheral vasoconstriction and reduced stroke volume.
An acute 24 h fasting reduces tolerance to central hypovolemia, and tolerance is negatively associated with blood ketone levels. Compared with a fed condition (3-h postprandial), fasted participants exhibited blunted peripheral vasoconstriction and greater reductions in stroke volume during stepwise lower body negative pressure. These findings suggest that a prolonged fast may lead to quicker decompensation during central hypovolemia.
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Gonzalez et al. (2023) conducted an RCT in Healthy (n=18). Acute fasting vs. Fed condition (3-h postprandial) was evaluated on Tolerance to central hypovolemia measured via total duration of negative pressure (seconds) (p=0.04). An acute 24-hour fast reduced tolerance to progressive central hypovolemia by approximately 10% (1,229 vs 1,370 seconds, P=0.04) compared to a 3-hour postprandial fed condition in healthy adults.
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