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September 4, 2014Current Heart Failure ReportsOpen Access

New Insights in (Inter)Cellular Mechanisms by Heart Failure with Preserved Ejection Fraction

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Key result

A systemic pro-inflammatory state induced by comorbidities drives microvascular endothelial cell inflammation, which subsequently triggers concentric cardiac remodeling and dysfunction in HFpEF.

Design

Review

Authors

Carsten Tschöpe
Carsten TschöpeHeart Failure & TransplantSLSophie Van LinthoutHeart Failure & Transplant

Discussion

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Overview

Supports endothelial inflammation as HFpEF mechanism; leaves open targeted therapies pending prospective trials.

PICO

P
Population
Heart failure with preserved ejection fraction (HFpEF)

Endothelial dysfunction driven by comorbidity-induced systemic inflammation is a central mechanism in the pathogenesis and cardiac remodeling of HFpEF.

Cite This Study

Tschöpe et al. (2014) conducted a review in Heart failure with preserved ejection fraction (HFpEF). A systemic pro-inflammatory state induced by comorbidities drives microvascular endothelial cell inflammation, which subsequently triggers concentric cardiac remodeling and dysfunction in HFpEF.

synapsesocial.com/papers/6a1728d22fcf950e0005ba78https://doi.org/10.1007/s11897-014-0219-3
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Also Consider

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