What question did this study set out to answer?

To determine whether reactive oxygen species activate AMP-activated protein kinase directly or secondary to shifts in cellular adenine nucleotide ratios.

September 20, 2018Journal of Biological ChemistryOpen Access

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

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To determine whether reactive oxygen species activate AMP-activated protein kinase directly or secondary to shifts in cellular adenine nucleotide ratios.
Concurrently measured AMPK enzymatic activity and cellular ATP/ADP ratios under conditions of mitochondrial reactive oxygen species production.
Differentiated direct oxidative modifications on AMPK from energetic perturbations caused by altered mitochondrial metabolism.
AMPK activation following redox fluctuations did not occur through direct action on the kinase complex itself.
Activation of AMPK occurred as a secondary consequence of disrupted mitochondrial ATP production and decreased ATP/ADP ratios.

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Implication

Experimental study demonstrates indirect activation of AMPK by mitochondrial ROS via ATP/ADP alterations, indicating redox signaling acts through energy pathways.

Cite This Study

Hinchy et al. (2018) studied this question.

synapsesocial.com/papers/6a1742db439273d98f785fb1 https://doi.org/10.1074/jbc.ra118.002579

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Implication

Experimental study demonstrates indirect activation of AMPK by mitochondrial ROS via ATP/ADP alterations, indicating redox signaling acts through energy pathways.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Key Points

Discussion

Implication

Cite This Study

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Key Points

Discussion

Implication

Cite This Study

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