Metronomic anti-cancer therapy – an ongoing treatment option for advanced cancer patients

Introduction The concept of using anti-angiogenic approaches as an anti-cancer treatment strategy was suggested by Judah Folkman in 1971 [1]. Three decades later the first approval of a 'new' anti-angiogenic agent was attained [2], although the debate of how to use bevacizumab optimally in which patients is still ongoing. Several physicians