Brachial artery flow-mediated dilation was not significantly different between older HFpEF patients and healthy older participants (3.64% vs 4.0%; p=0.86) and did not independently predict peak VO2.
Cross-Sectional (n=113)
Is brachial artery flow-mediated dilation reduced beyond normal aging and does it contribute to reduced peak VO2 in elderly HFpEF patients?
Endothelial dysfunction, as measured by flow-mediated dilation, does not appear to be a significant independent contributor to the severely reduced exercise capacity seen in elderly HFpEF patients beyond the effects of normal aging.
Tasa de eventos absoluta: 3.64% vs 4%
valor p: p=0.86
BACKGROUND: Older heart failure patients with preserved ejection fraction (HFpEF) have severely reduced exercise capacity and quality of life. Both brachial artery flow-mediated dilation (FMD) and peak exercise oxygen uptake (peak VO(2)) decline with normal aging. However, uncertainty remains regarding whether FMD is reduced beyond the degree associated with normal aging and if this contributes to reduced peak VO(2) in elderly HFpEF patients. METHODS: Sixty-six older (70 ± 7 years) HFpEF patients and 47 healthy participants (16 young, 25 ± 3 years, and 31 older, 70 ± 6 years) were studied. Brachial artery diameter was measured before and after cuff occlusion using high-resolution ultrasound. Peak VO(2) was measured using expired gas analysis during upright cycle exercise. RESULTS: Peak VO(2) was severely reduced in older HFpEF patients compared with age-matched healthy participants (15.2 ± 0.5 vs 19.6 ± 0.6 mL/kg/min, p < .0001), and in both groups, peak VO(2) was reduced compared with young healthy controls (28.5 ± 0.8 mL/kg/min; both p < .0001). Compared with healthy young participants, brachial artery FMD (healthy young, 6.13% ± 0.53%) was significantly reduced in healthy older participants (4.0 ± 0.38; p < .0002) and in HFpEF patients (3.64% ± 0.28%; p < .0001). However, FMD was not different in HFpEF patients compared with healthy older participants (p = .86). Although brachial artery FMD was modestly related to peak VO(2) in univariate analyses (r = .19; p = .048), it was not related in multivariate analyses that accounted for age, gender, and body size. CONCLUSION: These results suggest that endothelial dysfunction may not be a significant independent contributor to the severely reduced exercise capacity in elderly HFpEF patients.
Haykowsky et al. (Fri,) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) (n=113). Brachial artery flow-mediated dilation (FMD) assessment vs. Healthy older and young participants was evaluated on Brachial artery flow-mediated dilation (FMD) (p=0.86). Brachial artery flow-mediated dilation was not significantly different between older HFpEF patients and healthy older participants (3.64% vs 4.0%; p=0.86) and did not independently predict peak VO2.