Key result
The C allele of the KCNA4 gene rs1323860 was significantly more prevalent in fast Hispanic male marathon runners compared to slow runners (OR 1.33; 95% CI 1.17-1.51; P<0.001).
Why the study?
To test for an association between the KCNA4 rs1323860 variant and endurance performance level in Hispanic male marathon runners.
Is the KCNA4 gene rs1323860 variant associated with endurance running performance level in Hispanic male marathon runners?
Case-Control (n=1,876)
Is the KCNA4 gene rs1323860 variant associated with endurance running performance level in Hispanic male marathon runners?
The KCNA4 gene rs1323860 C allele is associated with higher endurance running performance in Hispanic male marathon runners.
Should not guide runner selection or training; hypothesis-generating for KCNA4 in endurance across populations.
The present is an observational study following a genetic epidemiology model using a case-control design. We tested the hypothesis of an association between the prevalence of the genotypic and allelic frequencies distribution of the potassium voltage-gated channel of the shaker related subfamily member 4 gene (KCNA4) rs1323860 (C/T transition) and endurance performance level in Hispanic male marathon runners (MR). The subjects (n=1876) were adult Hispanic male MR. Fast-MR (cases; n=938) were finishers in the top 3rd percentile. Slow MR (controls; n=938) were finishers in the lowest 3rd percentile of their respective age. Genomic DNA was purified from a whole blood sample. Polymerase chain reaction was used to amplify a KCNA4 SNP which consists of a C/T (rs1323860) transition. The observed genotype frequencies, in both Cases and Controls, met Hardy-Weinberg equilibrium (X2, P≥0.05). Genotype and allele frequencies were statistically different (P<0.01) between cases and controls. Odds ratio revealed that the C allele was 1.33 times more likely prevalent in the cases than in the controls (95% CI; 1.17, 1.51; P<0.001). The magnitude of the statistical power for the present study was 0.86. In conclusion, the findings strongly suggest that KCNA4 gene rs1323860 (C/T transition) is auxiliary in the complex phenotype of endurance running performance level in Hispanic male marathon runners.
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Flecha-Velazquez et al. (2019) conducted a case-control in Endurance running performance level (n=1,876). KCNA4 gene rs1323860 (C/T transition) C allele vs. Slow marathon runners (controls) was evaluated on Prevalence of the genotypic and allelic frequencies distribution of KCNA4 rs1323860 (OR 1.33, 95% CI 1.17, 1.51, p=<0.001). The C allele of the KCNA4 gene rs1323860 was significantly more prevalent in fast Hispanic male marathon runners compared to slow runners (OR 1.33; 95% CI 1.17-1.51; P<0.001).
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