Supplementary Figure from Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

Janine M. Buonato; Justin P. Edwards; Liubov Zaritskaya; Alexandra R. Witter; Ankit Gupta; David W. LaFleur; David A. Tice; Laura K. Richman; David M. Hilbert

doi:10.1158/1535-7163.22522626.v1

April 3, 2023Open Access

Supplementary Figure from Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

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Key Points

Evaluate the preclinical antitumor efficacy and binding performance of BCMA-directed CAR T cells incorporating a novel D domain antigen recognition domain.
Engineered CAR T-cell constructs using an alternative D domain antigen recognition moiety targeted to B-cell maturation antigen (BCMA).
Assessed in vitro cytotoxic activity, target binding affinity, and cell-mediated immune activation.
CAR T cells incorporating the novel D domain demonstrate selective binding and cytotoxic activity against BCMA-positive targets.
Preclinical testing supports the functionality of the D domain as a viable antigen-recognition platform for CAR T-cell designs.

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Implication

Preclinical study demonstrates antitumor activity of novel D domain-based BCMA CAR T cells, suggesting an alternative design for targeted cellular immunotherapy.

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Buonato et al. (2023) studied this question.

synapsesocial.com/papers/6a1786e80a2f3f8e141294d6 https://doi.org/10.1158/1535-7163.22522626.v1

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Supplementary Figure from Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure from Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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