Key result
Cardiovascular growth factors protect cardiomyocytes from acute ischaemia-reperfusion injury through the activation of cell-surface receptors and intracellular signal transduction pathways.
Cardiovascular growth factors may offer direct myocardial protection against ischaemia-reperfusion injury via specific intracellular signaling pathways, presenting potential for future clinical application.
Supports preclinical exploration of growth factor signaling in cardioprotection; leaves open clinical translation in ischaemia-reperfusion injury.
Many of the originally identified cardiovascular 'growth factors' have been demonstrated to exert a diverse variety of actions within the cardiovascular system, the majority of which are unrelated to their initially proposed mechanism of action. Interestingly, several of these growth factors have been demonstrated to protect the cardiomyocyte from the detrimental effects of acute ischaemia-reperfusion injury, through the activation of a variety of cell-surface receptors and the subsequent recruitment of a number of intracellular signal transduction pathways, which include components of the reperfusion injury salvage kinase pathway. This article will review several of these cardioprotective growth factors with respect to their ability to confer direct myocardial protection, focusing on the underlying signalling pathways involved and their potential for clinical application.
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Hausenloy et al. (2009) conducted a review in Acute ischaemia-reperfusion injury. Cardioprotective growth factors was evaluated. Cardiovascular growth factors protect cardiomyocytes from acute ischaemia-reperfusion injury through the activation of cell-surface receptors and intracellular signal transduction pathways.
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