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October 15, 2015EndocrinologyOpen Access

Cardiomyocyte-specific deletion of the IGF-1 receptor in male mice attenuated age-associated cardiac hypertrophy, fibrosis, and proinflammatory cytokine expression.

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Why the study?

Does deletion of IGF-1 receptors in cardiomyocytes attenuate cardiac aging and remodeling in male mice?

Population

2-year-old male cardiomyocyte-specific IGF-1R knockout mice, wild-type mice, and cultured cardiomyocytes

Comparison

Cardiomyocyte-specific deletion of IGF-1… vs Wild-type mice in vivo; phosphoinositide…

Design

Preclinical

Follow-up

2 years (age of mice)

Key result

Cardiomyocyte-specific deletion of the IGF-1 receptor in male mice attenuated age-associated cardiac hypertrophy, fibrosis, and proinflammatory cytokine expression.

Authors

SOSangmi OckWLWang Soo LeeJAJihyun Ahn

Discussion

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Member takes

Overview

Supports IGF-1R as a cardiac senescence target; leaves open human translation.

Structured PICO

Does deletion of IGF-1 receptors in cardiomyocytes attenuate cardiac aging and remodeling in male mice?

P
Population
2-year-old male cardiomyocyte-specific IGF-1R knockout (CIGF1RKO) mice, wild-type (WT) mice, and cultured cardiomyocytes
I
Intervention
Cardiomyocyte-specific deletion of IGF-1 receptor (IGF-1R) in vivo; IGF-1 treatment in vitro
C
Comparator
Wild-type (WT) mice in vivo; phosphoinositide 3-kinase inhibitor in vitro
O
Outcome
Cardiac hypertrophy, fibrosis, and expression of proinflammatory cytokines (IL-1α, IL-1β, IL-6, and RANKL)surrogate

The IGF-1-IGF-1R-Akt pathway plays an essential role in mediating cardiomyocyte senescence, and its deletion attenuates age-related cardiac remodeling.

Cite This Study

Ock et al. (2015) studied Cardiac aging. Cardiomyocyte-specific IGF-1R deletion vs. Wild-type was evaluated on Cardiac hypertrophy, fibrosis, and proinflammatory cytokine expression. Cardiomyocyte-specific deletion of the IGF-1 receptor in male mice attenuated age-associated cardiac hypertrophy, fibrosis, and proinflammatory cytokine expression.

synapsesocial.com/papers/6a1787a95fdf2a7b88aa1e86https://doi.org/10.1210/en.2015-1709
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Also Consider

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  1. 1Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy2010 · 147 citations
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  3. 3Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart2022 · 22 citations
  4. 4Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging2011 · 168 citations
  5. 5Influence of Age on Contractile Response to Insulin-Like Growth Factor 1 in Ventricular Myocytes From Spontaneously Hypertensive Rats1999 · 36 citations