Key result
Finger-worn pressure sensors capture 3D pulse signals demonstrating moderate correlation between radial augmentation index and age.
Observational (n=48)
No
A novel finger-worn flexible pressure-sensor array can accurately acquire three-dimensional arterial pulse signals, pulse width, and pulse wave velocity, offering potential for objective traditional Chinese medicine pulse diagnosis and arterial stiffness assessment.
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May support non-invasive arterial stiffness assessment; leaves open prospective validation before clinical adoption.
In this study, we developed a radial artery pulse acquisition system based on finger-worn dense pressure sensor arrays to enable three-dimensional pulse signals acquisition. The finger-worn dense pressure-sensor arrays were fabricated by packaging 18 ultra-small MEMS pressure sensors (0.4 mm × 0.4 mm × 0.2 mm each) with a pitch of 0.65 mm on flexible printed circuit boards. Pulse signals are measured and recorded simultaneously when traditional Chinese medicine practitioners wear the arrays on the fingers while palpating the radial pulse. Given that the pitches are much smaller than the diameter of the human radial artery, three-dimensional pulse envelope images can be measured with the system, as can the width and the dynamic width of the pulse signals. Furthermore, the array has an effective span of 11.6 mm-3-5 times the diameter of the radial artery-which enables easy and accurate positioning of the sensor array on the radial artery. This study also outlines proposed methods for measuring the pulse width and dynamic pulse width. The dynamic pulse widths of three volunteers were measured, and the dynamic pulse width measurements were consistent with those obtained by color Doppler ultrasound. The pulse wave velocity can also be measured with the system by measuring the pulse transit time between the pulse signals at the brachial and radial arteries using the finger-worn sensor arrays.
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Chen et al. (2021) conducted an observational in Healthy volunteers and patients with cardiovascular conditions (n=48). Finger-worn dense pressure-sensor arrays was evaluated on Correlation between radial artery augmentation index (AIr) and age (r = 0.683, p=<0.001). The finger-worn dense pressure-sensor array successfully acquired three-dimensional arterial pulse signals, demonstrating a moderate correlation between the radial artery augmentation index and age (r = 0.683, p < 0.001).
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